Research Article
Ductal Carcinoma In Situ of the Breast: Perspectives on Tumor Subtype and Treatment
Table 1
Patient characteristics within subgroups.
| | Variables | HoR+/HER- (%) | HoR+/HER+ (%) | HoR-/HER+ (%) | TN (%) | value |
| | Follow-up (months) | | | | | | | Age at diagnosis (y) | | | | | | | <35 | 11 (0.5) | 9 (1.2) | 3 (0.8) | 0 (0.0) | | | 35-49 | 417 (20.3) | 173 (22.6) | 68 (18.6) | 36 (15.3) | | | 50-64 | 808 (39.4) | 346 (45.2) | 171 (46.8) | 108 (46.0) | | | ≥65 | 814 (39.7) | 237 (31.0) | 123 (33.7) | 91 (38.7) | | | Grade | | | | | | | Well | 363 (17.7) | 39 (5.1) | 5 (1.4) | 7 (3.0) | | | Moderately | 810 (39.5) | 193 (25.2) | 38 (10.4) | 45 (19.1) | | | Poorly | 553 (27.0) | 406 (53.1) | 258 (70.7) | 143 (60.9) | | | Undifferentiated | 55 (2.7) | 35 (4.6) | 21 (5.8) | 12 (5.1) | | | Unknown | 269 (13.1) | 92 (12.0) | 43 (11.8) | 28 (11.9) | | | Tumor size (mm) | | | | | | | ≤10 | 847 (41.3) | 278 (36.3) | 109 (29.9) | 73 (31.1) | | | 10-20 | 396 (19.3) | 179 (23.4) | 89 (24.4) | 69 (29.4) | | | 20-50 | 209 (10.2) | 103 (13.5) | 64 (17.5) | 28 (11.9) | | | >50 | 60 (2.9) | 29 (3.8) | 17 (4.7) | 7 (3.0) | | | Unknown | 538 (26.2) | 176 (23.0) | 86 (23.6) | 58 (24.7) | | | Laterality | | | | | 0.254 | | Left | 1051 (51.3) | 388 (50.7) | 201 (55.1) | 110 (46.8) | | | Right | 999 (48.7) | 377 (49.3) | 164 (44.9) | 125 (53.2) | | | Radiotherapy | | | | | 0.480 | | None/unknown | 1052 (51.3) | 380 (49.7) | 183 (50.1) | 130 (55.3) | | | Yes | 998 (48.7) | 385 (50.3) | 182 (49.9) | 105 (44.7) | | | Local treatment | | | | | 0.009 | | M | 574 (28.0) | 252 (32.9) | 126 (34.5) | 90 (38.3) | | | BCS | 1402 (68.4) | 489 (63.9) | 222 (60.8) | 140 (59.6) | | | None | 69 (3.4) | 21 (2.7) | 15 (4.1) | 4 (1.7) | | | Unknown | 5 (0.2) | 3 (0.4) | 2 (0.5) | 1 (0.4) | | | Axillary treatment | | | | | | | None | 1285 (62.7) | 432 (56.5) | 188 (51.5) | 121 (51.5) | | | SLNB | 663 (32.3) | 290 (37.9) | 152 (41.6) | 101 (43.0) | | | ALND | 84 (4.1) | 37 (4.8) | 23 (6.3) | 12 (5.1) | | | Unknown | 18 (0.9) | 6 (0.8) | 2 (0.5) | 1 (0.4) | | | Status | | | | | | | Alive | 1998 (97.5) | 745 (97.4) | 356 (97.5) | 218 (92.8) | | | Dead | 52 (2.5) | 20 (2.6) | 9 (2.5) | 17 (7.2) | | | Breast cancer | 5 (0.2) | 3 (0.4) | 2 (0.5) | 6 (2.6) | | | Other | 47 (2.3) | 17 (2.2) | 7 (1.9) | 11 (4.7) | |
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values calculated by Pearson Chi -squared testing; bold if statistically significant, . y: years; mm: millimeter; y: years; BCS: breast-conserving surgery; HoR: hormone receptor; TN: triple negative; M: mastectomy; SLNB: sentinel lymph node biopsy; ALND: axillary lymph node dissection. |
