Disease Mutation Study Identifies Critical Residues for Phosphatidylserine Flippase ATP11A

Figure 1

Location and conservation analysis of mutations affected residues. (a) ATP8B1 and ATP11A protein sequence alignment of amino acid sequences surrounding the identified mutations with its orthologues from H. sapiens to X. tropicalis. The affected amino acid residues are in red. Note that the amino acid sequences of ATP11A surrounding the affected amino acid residues are highly conserved among Homo sapiens, Pan troglodytes, Macaca mulatta, Canis lupus, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus, Danio rerio, Xenopus tropicalis, Caenorhabditis elegans. (b) Schematic representation of exon-intron structure of Atp8b1 and Atp11a. (c) Topology of ATP11A with the location of the affected residues I80, Y300, and D913.

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