The Prognosis Analysis of Liver Cirrhosis with Acute Variceal Bleeding and Validation of Current Prognostic Models: A Large Scale Retrospective Cohort Study
Table 2
Predictors for overall survival in 379 patients with liver cirrhosis and GIB.
Variable
Univariate analysis
Multivariate analysis
OR
95% CI
OR
95% CI
Age
1.043
1.010-1.078
0.011
1.066
1.017-1.118
0.008
Gender (male/female)
1.041
0.455-2.381
0.925
Etiology (hepatitis/other)
0.378
0.165-0.865
0.021
AFP
1
1.000-1.000
0.898
HCC (yes/no)
5.417
2.355-12.458
<0.001
7.19
2.077-24.893
0.001
Diabetes (yes/no)
0.846
0.191-3.748
0.826
History of GIB (yes/no)
1.354
0.546-3.357
0.513
White blood cell
1.166
1.079-1.259
<0.001
1.123
1.051-1.201
0.001
Platelet
1.002
0.996-1.008
0.502
Red blood cell
0.26
0.125-0.541
<0.001
0.375
1.131-1.068
0.066
Hemoglobin
0.987
0.968-1.006
0.175
Albumin
0.902
0.837-0.972
0.007
1.164
1.031-0.913
0.623
Total serum bilirubin
1.013
1.005-1.020
0.001
1.014
1.005-1.023
0.003
Serum creatinine
1.017
1.007-1.026
<0.001
1.012
1.004-1.021
0.006
International normalized ratio
1.009
0.962-1.059
0.712
Alanine aminotransferase
1.008
1.003-1.012
0.001
1.005
1.000-1.009
0.036
Aspartate aminotransferase
1.004
1.002-1.006
<0.001
Alkaline phosphatase
1.002
1.000-1.004
0.036
0.794
0.995-1.006
0.794
Gamma-glutamyl transpeptidase
1
0.999-1.002
0.524
Child-Pugh score
2.219
1.695-2.905
<0.001
MELD score
2.789
1.743-4.462
<0.001
NLR score
1.046
1.017-1.075
0.002
CAGIB score
3.408
2.214-5.244
<0.001
HCC: hepatocellular carcinoma; OR: odds ratio; CI: confidence interval; AFP: α-fetoprotein; GIB: acute gastrointestinal bleeding; ALT: alanine aminotransferase; AST: aspartate aminotransferase. Child-Pugh score, MELD score, and NLR score are complex variables composed of many clinically significant variables, and therefore, they were not included in the multivariate analysis. ALT and AST had a potential collinearity for assessing liver function, and therefore, AST was excluded in the multivariate analysis.
