Review Article
Comparison of Intravenous versus Topical Tranexamic Acid in Nondeformity Spine Surgery: A Meta-Analysis
Table 2
Results of the meta-analysis of outcome measures.
| | Outcome and Subgroup | Number of studies | Patients I: T | RR/MD (95% CI) | Value | Heterogeneity Value (I2) |
| | Blood loss | | | | | | | IBL (mL) | 4 | 171/165 | −32.72 [−129.17, 63.72] | 0.51 | <0.00001 (97%) | | HBL (mL) | 3 | 136/130 | −76.73 [−178.30, 24.84] | 0.14 | <0.00001 (94%) | | TBL (mL) | 3 | 179/179 | −69.65 [−149.93, 10.64] | 0.09 | 0.03 (73%) | | HCT (%) | | | | | | | Preoperative HCT (%) | 2 | 106/100 | 0.51 [−0.50, 1.51] | 0.32 | 0.32 (1%) | | Postoperative HCT (%) | 2 | 106/100 | 1.87 [−0.48, 4.22] | 0.12 | 0.01 (85%) | | PT (seconds) | | | | | | | Preoperative PT (seconds) | 4 | 124/118 | −0.39 [−0.63, −0.15] | 0.002 | 0.21 (34%) | | Postoperative PT (seconds) | 5 | 144/138 | −0.21 [−0.54, 0.12] | 0.22 | 0.06 (57%) | | Hb level (g/L) | 2 | 70/64 | −0.74 [−4.67, 3.19] | 0.71 | 0.26 (23%) | | Preoperative Hb level (g/L) | | | | | | | Postoperative Hb level (g/L) | 3 | 100/94 | 1.84 [−3.38, 7.06] | 0.49 | 0.06 (65%) | | FIB (g/L) | | | | | | | Preoperative FIB (g/L) | 3 | 99/93 | −0.10 [−0.32, 0.12] | 0.37 | 0.02 (73%) | | Postoperative FIB (g/L) | 3 | 99/93 | 0.02 [−0.10, 0.14] | 0.72 | 0.90 (0%) | | APTT (seconds) | | | | | | | Preoperative APTT (seconds) | 3 | 79/79 | 1.12 [0.57, 1.68] | <0.0001 | 0.93 (0%) | | Postoperative APTT (seconds) | 3 | 79/79 | −0.30 [−2.47, 1.87] | 0.79 | <0.0001 (91%) | | Drainage volume | 4 | 120/114 | −5.97 [−19.04, 7.10] | 0.37 | 0.44 (0%) | | Blood transfusion rate | 4 | 140/134 | 0.91 [0.60, 1.40] | 0.68 | 0.95 (0%) |
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IBL, intraoperative blood loss; HBL, hidden blood loss; TBL, total blood loss; HCT, hematocrit; PT, prothrombin time; Hb, hemoglobin; FIB, fibrinogen; APTT, activated partial thromboplastin time; I, intravenous; T, topical; RR, risk ratio; MD, mean difference.
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