BioMed Research International

Review Article

Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019

Table 1

Cardiac laboratory markers of COVID-19 patients.
PatientsLDHCKCK-MBcTnIMbα-HBDHASTNT-proBNP
[29]29/40 (73)
ICU 12/13 (92)
No-ICU 17/27 (63)		13/40 (33)
ICU 6/13 (46)
No-ICU 7/27 (26)		—5/41 (12)
ICU 4/13 (31)
No-ICU 1/28 (4)		——15/41 (37)
ICU 8/13 (62)
No-ICU 7/28 (25)		—
[45]75/99 (76)13/99 (13)——15/99 (15)—35/99 (35)—
[2]129/188 (68.6)21/188 (11.2)19/188 (10.1)21/188 (11.2)—143/188 (76.1)——
[31]57/267 (21.3)
39/217 (18.0)
Nonsevere
39/50 (18.0)
Severe		50/267 (18.7)
32/217 (14.7)
Nonsevere
18/50 (36.0)
Severe		—3/76 (3.9)
0/55 (0)
Nonsevere
3/21 (14.3)
Severe		8/76 (10.5)
1/55 (1.8)
Nonsevere
7/21 (33.3)
Severe		———
[46]—4/60 (6.7)
1/35 (2.8)
Nonsevere
3/25 (12.0)
Severe		——————
[47]277/675 (41.0)90/657 (13.7)————168/757 (22.2)—
[16]11/12 (91.7)1/6 (16.7)1/12 (8.3)1/12 (8.3)2/12 (16.7)—2/12 (16.7)—
[48]17/62 (27.4)5/62 (8.1)————10/62 (16.1)—
[49]——32/101 (31.68)
Admission to ICU
56/101 (55.45)
48 h to death		51/101 (50.50)
Admission to ICU
73/101 (72.28)
48 h to death		———37/101 (36.63)
Admission to ICU
41/101 (40.59)
48 h to death
[50]6/19 (31.58)1/18 (5.56)———6/8 (75.0)5/18 (27.78)—
[51]52/148 (35.1)—————32/148 (21.6)—
[52]20/29 (69)———————
[53]1/2 (50)———————
[30]68/73 (93.2)25/72 (34.7)21/70 (30.0)52/60 (86.7)42/70 (60.0)—44/72 (61.1)—
[54]9/46 (19.6)2/46 (4.4)————3/46 (6.5)—
2 [55]37/102 (36.3)19/102 (18.6)11/102 (10.8)—4/59 (6.8)37/102 (36.3)26/102 (25.5)—
[56]———137/200 (68.5)
112/166 (67.5)
Alive cases
25/34 (73.5)
Dead cases		————
[57]10/34 (29.4)———————
[58]——————3/9 (33.3)—
Laboratory data is reported as percent of patients with abnormalities defined according to the local reference ranges. No./total No. (%); ICU: intensive care unit; LDH: lactose dehydrogenase; CK: creatine kinase; CK-MB: creatinine kinase-muscle/brain activity; cTnI: cardiac troponin I; Mb: myoglobin; α-HBDH: alpha-hydroxybutyrate dehydrogenase; AST: aspartate aminotransferase; NT-proBNP: N-terminal of the prohormone brain natriuretic peptide.