Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells

Figure 3

Quantification of TAV effects in human cells. (a) TAV-induced reduction of DNA/RNA hybrids in HEK293T cells. Boxplots and descriptive statistics of the fluorescence signal data in HEK293T cells. The interquartile ranges show that the cell-associated fluorescence signal values of EV and TAV are well concentrated around their median values, whereas nontransfected and CP values show higher dispersion. A high-fluorescence outlier has been identified for the EV control. (b) TAV-induced cytotoxic effects in U251 cells. Boxplots and descriptive statistics of the cytotoxicity data in U251 cells. Each box shows the first and third quartiles (bottom and top horizontal lines, respectively: box height is the interquartile range, IQR) and the median value (thick horizontal line) and whiskers’ (vertical lines) ends are the lowest/highest datum within 1.5 × IQR from the box extremities; all values outside these intervals are considered as outliers (black dots). Tables collect sample size, median, and the interquartile range (IQR, i.e., the difference between the third and first quartiles).

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