Research Article
Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study
Table 2
Stability software predictions and DDG scores for the 19 deleterious nsSNPs of the RRM2B gene.
| | dbSNP ID | SNP | I-Mutant | Mupro | | Prediction | DDG value | Prediction | DDG value |
| | rs515726181 | R41W | Decrease | -0.57 | Decrease | -1.809 | | rs200273673 | R41P | Decrease | -1.06 | Decrease | -2.19 | | rs267607025 | R110P | Decrease | -1.47 | Decrease | -1.312 | | rs515726187 | F123S | Decrease | -2.49 | Decrease | -1.688 | | rs1211197364 | Y124C | Increase | 0.56 | Decrease | -0.935 | | rs1185904532 | E131A | Decrease | -0.04 | Decrease | -1.24 | | rs515726188 | E131K | Decrease | -0.63 | Decrease | -1.644 | | rs1313813193 | S139R | Decrease | -0.75 | Decrease | -0.849 | | rs1169870960 | I142T | Decrease | -2.42 | Decrease | -3.633 | | rs515726190 | R186G | Decrease | -1.91 | Decrease | -1.33 | | rs515726191 | E194G | Decrease | -2.61 | Decrease | -1.121 | | rs121918308 | E194K | Decrease | -1.5 | Decrease | -0.523 | | rs515726192 | G195R | Decrease | -0.82 | Decrease | -0.393 | | rs863224192 | G200E | Decrease | -0.94 | Decrease | -0.399 | | rs1283028277 | F206V | Decrease | -2.2 | Decrease | -1.157 | | rs575109470 | G216R | Decrease | -1.08 | Decrease | -0.503 | | rs1422185855 | D227V | Decrease | -0.92 | Decrease | -0.507 | | rs772868983 | H231Q | Decrease | -0.62 | Decrease | -0.199 | | rs1215473912 | A235T | Decrease | -1.63 | Decrease | -1.261 |
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