The Impact of the NOD2/CARD15 Variant (3020insC) and PSMA6 Polymorphism (-8C>G) on the Development and Outcome of Multiple Myeloma

Table 6

Univariate Cox analysis in the survival of MM patients.

Variable	Univariate Cox analysis for OS			Univariate Cox analysis for PFS
	value	HR	95% CI	value	HR	95% CI
ISS
I+II	—	R	—	—	R	—
III	0.003	1.69	1.18-2.41	<0.001	1.68	1.27-2.22
Auto-HSCT
Yes	—	R	—	—	R	—
No	<0.001	5.30	2.11-13.34	0.002	2.54	1.37-4.70
PSMA6
CC	—	R	—	—	R	—
CG+GG	0.13	0.43	0.14-1.31	0.33	1.15	0.15-3.96
NOD2/CARD15
Wild type	—	R	—	—	R	—
Mutated	0.49	0.73	0.29-1.78	0.93	0.97	0.45-2.06
PSMA6 and NOD2/CARD15
CC+wild type	—	R	—	—	R	—
CG+GG+mutated	0.60	1.68	0.22-12.58	0.25	3.14	0.43-22.97

R: reference.