The Impact of the NOD2/CARD15 Variant (3020insC) and PSMA6 Polymorphism (-8C>G) on the Development and Outcome of Multiple Myeloma

Table 8

NOD2/CARD15 mutation and PSMA6 polymorphism in the response rate of MM patients.

Variable	Response rate
	CR+VGPR+PR+SD	PD
	value	OR (95% CI)
ISS
I+II	—	Reference
III	<0.001	5.44 (2.14-13.84)
Auto-HSCT
Yes	—	Reference
No	0.015	3.36 (1.22-9.25)
PSMA6
CC	—	Reference
CG+GG	0.05	5.0 (1.07-23.16)
NOD2/CARD15
Wild type	—	Reference
Mutated	0.09	0.4 (0.13-1.18)
PSMA6 and NOD2/CARD15
CC+wild type	—	Reference
CG+GG+mutated	0.42

Too small group for analysis. CR: complete response; VGPR: very good partial response; PR: partial response; SD: stable disease; PD: progressive disease patients—according to the response criteria for MM [14, 15].