The Impact of the NOD2/CARD15 Variant (3020insC) and PSMA6 Polymorphism (-8C>G) on the Development and Outcome of Multiple Myeloma

Table 9

The clinical values of MM patients included to the study taking into account the studied polymorphisms.

Variables	MM patients	NOD2/CARD15			PSMA6
		Wild type	Mutated	value	CC	CG+GG	value
Mean age (years)	65.32	65.20	65.93	0.78	65.39	65.0	0.87
Free light chain ratio	303	241.41	617.37	0.08	324.44	217.14	0.59
% of plasma cells in bone marrow	30.75	31.18	28.40	0.62	30.05	33.88	0.47
Albumins (g/dl)	3.57	3.58	3.56	0.91	3.53	3.75	0.20
β2-Microglobulin (mg/l)	5.98	5.79	6.93	0.30	6.26	4.81	0.15
Calcium (mM/l)	2.45	2.43	2.53	0.27	2.45	2.43	0.81
Hemoglobin (g/dl)	10.38	10.39	10.33	0.91	10.35	10.51	0.74
Creatinine (mg/dl)	1.57	1.49	1.98	0.28	1.69	1.07	0.16
C-reactive protein (mg/l)	15.68	14.0	23.68	0.31	16.57	12.26	0.63
Estimated glomerular filtration rate (ml/min/1.73 m^2)		70.0	57.99	0.15	66.18	76.19	0.20
PFS (months)	18.32	18.59	16.87	0.73	18.25	18.57	0.94
OS (months)	31	26.94	21.31	0.43	26.24	25.15	0.87

At diagnosis.