Protective Effect of Iridoid Glycosides of the Leaves of Syringa oblata Lindl. on Dextran Sulfate Sodium-Induced Ulcerative Colitis by Inhibition of the TLR2/4/MyD88/NF-κB Signaling Pathway

Figure 2

Iridoid glycosides attenuated changes in DAI score, macroscopic score, and body weight loss in DSS-induced colitis. Rats were treated orally at different doses of IG 20, 40, and 80 mg/kg once for 14 days after administration of DSS. The severity of colonic injury and the clinical evaluation were measured by (a) DAI score, (b) macroscopic score, and (c) body weight. IG administration dose dependently attenuated these pathological parameters. Data are presented as the ( per group). ^## vs. the normal control group, vs. the DSS-induced colitis group, ^§§ vs. the IG (20 mg/kg)+DSS group, and ^★★ vs. the IG (40 mg/kg)+DSS group.

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