Repairing and Analgesic Effects of Umbilical Cord Mesenchymal Stem Cell Transplantation in Mice with Spinal Cord Injury

<div>Results of pain threshold measurement in each group of mice at each time point. Four weeks after hUC-MSC transplantation (5 weeks after SCI), mice in each group were tested every two weeks (5, 7, and 9 weeks after SCI). The von Frey wire was used to vertically stimulate the skin surface under the foot of the hind paw, and the pressure (g) at which paw withdrawal occurred was recorded. The median value was measured four times at 2 min intervals to get the pain threshold (g). For the same time point, the pain threshold of the hUC-MSC treatment group was significantly higher than that of the model group (<span class="nowrap"><svg height="9.2729pt" id="M19" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 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BioMed Research International

fig4

Figure 4

Figure 4: Repairing and Analgesic Effects of Umbilical Cord Mesenchymal Stem Cell Transplantation in Mice with Spinal Cord Injury 