Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions

Figure 5

Concentrations of triglyceride (TG), high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL) in sera from rabbits administered a cholesterol diet and aspirin. (a) TG level was higher in the cholesterol-diet rabbits than that of the control rabbits, and it was lower in the aspirin-administered rabbits. (b) HDL-cholesterol level was more significantly elevated in the aspirin-administered rabbits than that of the cholesterol-diet rabbits without aspirin. (c) LDL-cholesterol level was higher in the cholesterol-diet rabbits than that of the control rabbits, and it was not decreased in the aspirin-administered rabbits. (D, E) ALT and AST levels were higher in the cholesterol-diet rabbits than those of the control rabbits; however, they were decreased in the aspirin-administered rabbits. The results are expressed as (). Values were statistically analyzed by unpaired -test or one-way ANOVA. An upper line on the three bars means one-way ANOVA analysis. All experiments were repeated three and over times. Meaning of indications: Ctrl means normal control rabbits administered with normal, C means rabbits fed with 1% cholesterol diet, and CA means rabbits administered with 1% cholesterol diet plus aspirin of 100 mg/kg/day. , , .

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