Influence of Geographical and Seasonal Variations on Carbazole Alkaloids Distribution in <i>Murraya koenigii</i>: Deciding Factor of Its <i>In Vitro</i> and <i>In Vivo</i> Efficacies against Cancer Cells

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Ovarian cancer cell lines</td><td class="align_center" colspan="3">IC50 (<i>μ</i>M)</td></tr><tr class="thead"><td class="align_center">Mahanine</td><td class="align_center">Mahanimbine</td><td class="align_center">Koenimbine</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">PA1</td><td class="align_center">11 ± 0.2</td><td class="align_center">28 ± 0.11</td><td class="align_center">51 ± 0.25</td></tr><tr><td class="align_left">OVCAR3</td><td class="align_center">32 ± 0.18</td><td class="align_center">52 ± 0.05</td><td class="align_center">68 ± 0.22</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Cells were treated separately with mahanimbine and koenimbine for 48 h, and mahanine was used as the control for comparison [<a href="/journals/bmri/2020/7821913/#B8" target="_blank">8</a>]. IC50 values were compared. These data were derived from three individual experiments, and mean ± SD was indicated.<br/></div></td></tr></table>

<div>Reduced metabolic activity by three carbazole alkaloids from MEF against ovarian cancer.</div>

BioMed Research International

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Table 3

Table 3: Influence of Geographical and Seasonal Variations on Carbazole Alkaloids Distribution in <i>Murraya koenigii</i>: Deciding Factor of Its <i>In Vitro</i> and <i>In Vivo</i> Efficacies against Cancer Cells 

Table 3 | Influence of Geographical and Seasonal Variations on Carbazole Alkaloids Distribution in Murraya koenigii: Deciding Factor of Its In Vitro and In Vivo Efficacies against Cancer Cells 