Influence of Geographical and Seasonal Variations on Carbazole Alkaloids Distribution in Murraya koenigii: Deciding Factor of Its In Vitro and In Vivo Efficacies against Cancer Cells

Table 4

Seasonal variation of three markers and antiproliferative activity of MEF_WB.

The month of collection of leaflets	Mahanine (%)	Mahanimbine (%)	Koenimbine (%)	MEFWB IC50 (μg/ml)
February	5 ± 1.5	12 ± 1.4	15 ± 1.8	73.2 ± 0.15
April	5 ± 1.9	11 ± 1.8	12 ± 1.2	71.0 ± 0.5
May	6 ± 1.7	9 ± 1.5	8 ± 0.9	68.0 ± 0.14
July	9 ± 1.6	16 ± 1.2	8 ± 1.5	55.0 ± 0.3
September	12 ± 1.8	18 ± 1.6	10 ± 1.1	39.0 ± 0.3
December	14 ± 1.5	20 ± 1.6	11 ± 1.25	37.0 ± 0.2

Composition of markers in MEF_WB in different seasons and their IC50. These are representative data collected in one year. MEF_WB: mahanine-enriched fraction prepared from West Bengal leaflets. These data were derived from three individual experiments, and mean ± SD was indicated.