99-Case Study of Sporadic Aortic Dissection by Whole Exome Sequencing Indicated Novel Disease-Associated Genes and Variants in Chinese Population

Table 4

AD-associated genes in Novo zhonghua database correlation analysis.

Gene	Alt_case	Ref_case	Alt_control	Ref_control	value
ACTA2	4	194	5	5649	0.00014
FBN1	8	190	99	5555	0.02789
SLC2A10	3	195	30	5624	0.09926
ELN	3	195	46	5608	0.2297
MYH11	5	193	87	5567	0.24114
TGFBR2	2	196	27	5627	0.25712
COL5A1	1	197	105	5549	0.26919
NOTCH1	2	196	130	5524	0.32839
TGFB2	1	197	11	5643	0.33863
COL3A1	2	196	36	5618	0.37014
FBN2	6	192	124	5530	0.4541
PLOD1	2	196	54	5600	0.71451
COL5A2	2	196	79	5575	1
MYLK	2	196	60	5594	1

Gene: gene name; Alt_case: number of mutated alleles in our 99 cases; Ref_case: number of nonmutated alleles in 99 cases; Alt_control: number of mutated alleles in control 2827 Novo zhonghua cases; Ref_control: number of nonmutated alleles in control 2827 Novo zhonghua cases; value: value obtained by Fisher’s test between our cases and cases in Novo zhonghua database.