Identification of a Seven-lncRNA Immune Risk Signature and Construction of a Predictive Nomogram for Lung Adenocarcinoma

Table 3

Univariate and multivariate Cox analyses of the risk signature and clinicopathological features for the independent prognostic value in lung adenocarcinoma patients.

	Variables	Univariate Cox regression analysis
		HR	95% CI lower	95% CI higher	value
Training set	Age	1.015	0.991	1.039	0.224
	Gender	0.959	0.609	1.511	0.857
	TNM stage	1.625	1.331	1.984	<0.001
	Risk signature	2.841	1.895	4.258	<0.001
Validation set	Age	1.004	0.981	1.028	0.712
	Gender	1.213	0.771	1.908	0.405
	TNM stage	1.734	1.395	2.155	<0.001
	Risk signature	1.765	1.217	2.561	0.003
Combination set	Age	1.010	0.993	1.027	0.244
	Gender	1.054	0.765	1.452	0.748
	TNM stage	1.689	1.460	1.955	<0.001
	Risk signature	2.215	1.706	2.876	<0.001
	Variables	Multivariate Cox regression analysis
		HR	95% CI lower	95% CI higher	value
Training set	TNM stage	1.870	1.160	3.015	0.01
	Risk signature	2.540	1.653	3.904	<0.001
Validation set	TNM stage	2.664	1.622	4.376	<0.001
	Risk signature	1.539	1.075	2.204	0.019
Combination set	TNM stage	2.274	1.611	3.210	<0.001
	Risk signature	1.922	1.469	2.515	<0.001

HR: hazards ratio; CI: confidence interval.