Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis

Table 2

Summary of results from different comparative genetic models.

Comparison	Stratification	No	OR (95% CI)		(%) ()	Model
GG + GA vs. AA	Overall	24	0.92 [0.79, 1.07]	0.27	61 (<0.01)	Random
	HWE	20	0.94 [0.79, 1.13]	0.51	60 (<0.01)	Random
	Caucasian	14	0.95 [0.76, 1.19]	0.65	62 (<0.01)	Random
	Asian	4	0.84 [1.57, 1.25]	0.39	63 (0.04)	Random
	Shock	9	1.01 [0.84, 1.22]	0.91	50 (0.05)	Fixed
	Mortality	19	0.57 [0.41, 0.80]	<0.01	63 (<0.01)	Random
GG vs. GA + AA	Overall	25	0.92 [0.84, 1.02]	0.12	26 (0.12)	Fixed
	HWE	18	1.01 [0.88, 1.15]	0.93	14 (0.29)	Fixed
	Caucasian	12	1.08 [0.90, 1.30]	0.39	19 (0.26)	Fixed
	Asian	7	0.82 [0.68, 0.99]	0.04	0 (0.72)	Fixed
	Shock	8	0.92 [0.70, 1.22]	0.58	38 (0.13)	Fixed
	Mortality	19	0.73 [0.57, 0.93]	0.01	28 (0.13)	Fixed
GG vs. AA	Overall	22	0.94 [0.79, 1.12]	0.48	39 (0.03)	Random
	HWE	18	0.99 [0.85, 1.15]	0.92	29 (0.12)	Fixed
	Caucasian	12	1.04 [0.86, 1.26]	0.70	29 (0.17)	Fixed
	Asian	4	0.84 [0.65, 1.07]	0.15	0 (0.91)	Fixed
	Shock	5	1.02 [0.71, 1.46]	0.92	39 (0.16)	Fixed
	Mortality	17	0.52 [0.31, 0.85]	0.009	56 (<0.01)	Random
G vs. A	Overall	22	0.94 [0.85, 1.03]	0.19	56 (<0.01)	Random
	HWE	18	0.95 [0.85, 1.07]	0.41	50 (<0.01)	Random
	Caucasian	12	0.96 [0.83, 1.12]	0.63	53 (0.01)	Random
	Asian	4	0.91 [0.80, 1.03]	0.13	27 (0.25)	Fixed
	Shock	5	0.97 [0.82, 1.13]	0.67	49 (0.10)	Fixed
	Mortality	17	0.70 [0.54, 0.90]	0.005	67 (<0.01)	Random
GA vs. AA	Overall	22	0.89 [0.77, 1.03]	0.13	53 (0.002)	Random
	HWE	18	0.89 [0.74, 1.06]	0.19	54 (0.003)	Random
	Caucasian	12	0.86 [0.69, 1.07]	0.18	53 (0.02)	Random
	Asian	4	0.86 [0.54, 1.36]	0.51	69 (0.02)	Random
	Shock	5	0.54 [0.18, 1,61]	0.27	94 (<0.01)	Random
	Mortality	17	0.61 [0.44, 0.86]	0.004	57 (0.002)	Random