Inhibition of Wilms’ Tumor Proliferation and Invasion by Blocking TGF-β Receptor I in the TGF-β/Smad Signaling Pathway

Figure 1

High expression of TGF-β1 and P-Smad2/3 in Wilms’ tumor tissue. Immunohistochemical staining for TGF-β1 and P-Smad2/3 in Wilms’ tumors and adjacent normal tissues. (a–f), (g–l), (m–r), and (s–x) represent the specimen from the same patient, respectively. (a–f) Negative expression of TGF-β1 and P-Smad2/3 proteins. (g–l, m–k, and s–x) Staining intensity (weak, moderate, strong) for TGF-β1 and P-Smad2/3. Compared with the adjacent normal tissues, the expression of TGF-β1 and P-Smad2/3 was significantly increased (, ).