Inhibition of Wilms’ Tumor Proliferation and Invasion by Blocking TGF-β Receptor I in the TGF-β/Smad Signaling Pathway

Figure 3

TGF-β receptor I (TβRI) inhibitor suppressed WT growth in vivo. (a) Representative macroscopic findings of Wilms’ tumor. Two tumor-bearing mice from the control group died at day 65 after treatment. Tumor size () and final tumor weight () of G401 tumor cells after treatment with TβRI kinase inhibitor (60 mg/day) or PBS (control). (b) The toxicity of TβRI kinase inhibitor was determined by assessing the liver and kidney markers (blood urea nitrogen, serum creatinine, serum uric acid, and total bilirubin). The concentration of these markers was not significantly different between the two groups (#).

(a)

(b)

(c)