Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Table 2

Associations between BA-CA and different variables.

Variables		(95% CI)
Height (cm)	0.01	(0.01, 0.01)	<0.001
Height SDS	0.44	(0.30, 0.58)	<0.001
Body weight (kg)	0.03	(0.02, 0.03)	<0.001
BMI (kg/m^2)	0.11	(0.08, 0.14)	<0.001
BMI SDS	0.25	(0.17, 0.32)	<0.001
IGF-1 (ng/ml)	0.01	(0.01, 0.02)	<0.001
IGF-1 SDS	0.22	(0.15, 0.28)	<0.001
FT3 (pmol/l)	0.07	(0.00, 0.14)	0.050
FT4 (pmol/l)	0.01	(-0.01, 0.01)	0.383
TSH (mIU/l)	-0.01	(-0.07, 0.05)	0.757
ALP (U/l)	0.01	(-0.01, 0.01)	0.135
E2 (pg/ml)	0.01	(0.01, 0.02)	<0.001
T (pg/ml)	0.24	(0.15, 0.33)	<0.001
FSH (mIU/ml)	0.02	0.02 (0.01, 0.04)	0.006
LH (mIU/ml)	0.15	(0.09, 0.21)	<0.001
Sex
Male	Reference
Female	0.41	(0.23, 0.59)	<0.001
Pubertal stage
In prepuberty (%)	Reference
In puberty (%)	0.49	(0.31, 0.68)	<0.001

Abbreviations: BA-CA: bone age-chronological age; height SDS: height standard deviation scores; BMI: body mass index; BMI SDS: body mass index standard deviation scores; IGF-1: insulin-like growth factor-1; IGF-1 SDS: insulin-like growth factor-1 standard deviation scores; FT3: triiodothyronine; FT4: free thyroxine; TSH: thyrotrophic hormone; ALP: alkaline phosphatase; E2: estradiol; T: testosterone; FSH: follicle stimulating hormone; LH: luteinizing hormone. is considered to be statistically significant.