Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway
Platelet-rich plasma (PRP) combined with alendronate (ALN) delayed the progression of osteoarthritis (OA) in rat. (a) Representative histologic pictures of hematoxylin and eosin (H&E) and Safranin O staining (Scale bar, 200 mm). (b) The Mankin score of rat cartilages. (c) The OARIS score of rat cartilages. (d) The tender threshold of rats. (e) The thermal pain threshold of rats. Control, rats without any treatment. compared with the Control group. # and ## compared with the OA group. && compared with the ALN group. $,$$ compared with the PRP group.
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