High-Fat Diet Induced Hedgehog Signaling Modifications during Chronic Kidney Damage

Figure 6

HFD induces remarkable variations in hedgehog pathway genes; especially, Shh, Gli1, Gli2, Gli3, Ihh, and Smo were downregulated. Serum urea concentrations were elevated and tubular necrosis, glomerular edema, glomerular shrinkage, and hypocellularity were induced in kidneys. Fibrosis was also confirmed by significant collagen deposition in both HFD groups. Too much dietary intake of fats impaired normal kidney functioning and fibrotic kidney triggers on Hh signaling in adult rats suggesting chronic kidney disease.