Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy

Figure 2

VPA-responsive rate among different combinations of genotypes. The responsive rate of AA-CG+GG group or AG-CG+GG group was significantly higher than that of the GG-CC group ( values were 0.007 and 0.028, respectively) in (a). The responsive rate of AG+GG-GT group or AG+GG-GG group was significantly lower than that of the AA-GT group ( values were 0.047 and 0.013, respectively) in (b). The responsive rate of TA+AA-GG group, TT-GG group, or TA+AA-GT+TT was significantly higher than that of the TT-GT+TT group ( values were 0.046, 0.016, and 0.023, respectively) in (c). VPA: valproic acid.