Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy

Table 3

SNP-SNP interaction analysis among 31 studied single-nucleotide polymorphisms.

Chromosome	Gene	SNPs	Chromosome	Gene	SNPs	value
2:166122240	SCN1A	rs7587026	2:165270773	SCN2A	rs2119067	0.046
2:166035836	SCN1A	rs11691603	2:165270773	SCN2A	rs2119067	0.025
2:166069891	SCN1A	rs2162600	2:165307150	SCN2A	rs7598931	0.033
2:166035836	SCN1A	rs11691603	2:165283510	SCN2A	rs6740895	0.028
2:166122240	SCN1A	rs7587026	2:165283510	SCN2A	rs6740895	0.026
2:165310162	SCN2A	rs2116658	2:165268464	SCN2A	rs10197716	0.029
2:165290104	SCN2A	rs11889342	2:165283510	SCN2A	rs6740895	0.048
2:165337455	SCN2A	rs13387970	2:165304831	SCN2A	rs13012293	0.028
2:165268464	SCN2A	rs10197716	2:165270664	SCN2A	rs2119068	0.009
2:165268464	SCN2A	rs10197716	2:165290104	SCN2A	rs11889342	0.001
2:165290104	SCN2A	rs11889342	2:165330368	SCN2A	rs3769947	0.013
2:166053034	SCN1A	rs3812718	4:69096731	UGT2B7	rs12233719	0.017
2:166065518	SCN1A	rs13397210	4:69096731	UGT2B7	rs12233719	0.010
2:166071149	SCN1A	rs1020852	4:69096731	UGT2B7	rs12233719	0.013
2:165310162	SCN2A	rs2116658	4:69105219	UGT2B7	rs10028494	0.015
2:165337455	SCN2A	rs13387970	4:69107059	UGT2B7	rs5013211	0.026
2:165307150	SCN2A	rs7598931	4:69107059	UGT2B7	rs5013211	0.012
2:165307150	SCN2A	rs7598931	4:69096731	UGT2B7	rs12233719	0.001
2:165310162	SCN2A	rs2116658	4:69096731	UGT2B7	rs12233719	0.024

SNPs: single-nucleotide polymorphisms.