BioMed Research International / 2020 / Article / Tab 1 / Research Article
Potential of Using Cell-Free DNA and miRNA in Breast Milk to Screen Early Breast Cancer Table 1 Dysregulated miRNAs in breast cancer with extremely low or high basal abundance in BM. The inferential expression changes in early breast cancer (BC) are analyzed according to reports and basal abundance data from miRNA sequencing.
miRNA name miRNA sequence Normalized reads Inferential expression in early BC cfRNA4 cfRNA3 cellRNA3 cellRNA4 hsa-miR-25-5p_R+2 AGGCGGAGACTTGGGCAATTGCT 35 42 28 43 Upregulated hsa-miR-34a-3p_R+1 CAATCAGCAAGTATACTGCCCTT 0 0 0 8 Upregulated hsa-miR-92a-2-5p GGGTGGGGATTTGTTGCATTAC 7 0 0 0 Upregulated hsa-miR-103a-2-5p AGCTTCTTTACAGTGCTGCCTTG 36 7 53 43 Upregulated hsa-miR-125b-1-3p ACGGGTTAGGCTCTTGGGAGCT 10 25 10 10 Upregulated hsa-miR-133a-3p_L-1R+1 TTGGTCCCCTTCAACCAGCTGT 8 4 7 2 Upregulated hsa-miR-155-3p CTCCTACATATTAGCATTAACA 0 0 5 4 Upregulated hsa-miR-191-3p_R-3 GCTGCGCTTGGATTTCGTC 30 14 7 0 Upregulated hsa-miR-192-3p_R+1 CTGCCAATTCCATAGGTCACAGT 0 0 0 4 Upregulated hsa-miR-195-3p_R-2 CCAATATTGGCTGTGCTGCT 50 42 43 40 Upregulated hsa-miR-199a-5p_R-1 CCCAGTGTTCAGACTACCTGTT 22 23 20 19 Upregulated hsa-miR-200c-5p CGTCTTACCCAGCAGTGTTTGG 18 6 65 25 Upregulated hsa-miR-202 AGAGGTATAGCGCATGGGAA 0 0 0 0 Upregulated hsa-miR-215-5p_R+1 ATGACCTATGAATTGACAGACA 0 0 18 26 Upregulated hsa-mir-222-p5 AAGGTGTAGGTACCCTCAAT 0 0 8 16 Upregulated hsa-miR-299-5p TGGTTTACCGTCCCACATACAT 0 0 0 0 Upregulated hsa-miR-373 GAAGTGCTTCGATTTTGGGGTGT 0 0 0 0 Upregulated hsa-miR-375-5p GCGACGAGCCCCTCGCACAAACC 19 12 0 0 Upregulated hsa-miR-376c AACATAGAGGAAATTCCACGT 0 0 0 0 Upregulated hsa-miR-382-5p GAAGTTGTTCGTGGTGGATTCG 17 0 0 10 Upregulated hsa-miR-382-3p_R+1 AATCATTCACGGACAACACTTT 0 0 0 4 Upregulated hsa-miR-409-5p_R-1 AGGTTACCCGAGCAACTTTGCA 14 0 0 23 Upregulated hsa-miR-409-3p_L+1 CGAATGTTGCTCGGTGAACCCCT 0 0 0 6 Upregulated hsa-miR-523-3p_L-1R-2 AACGCGCTTCCCTATAGAGG 11 19 8 0 Upregulated hsa-miR-526b-5p_R-1 CTCTTGAGGGAAGCACTTTCTG 7 25 32 14 Upregulated hsa-miR-625-5p_R-1 AGGGGGAAAGTTCTATAGTC 7 0 15 12 Upregulated hsa-let-7a-5p TGAGGTAGTAGGTTGTATAGTT 69874 57909 83431 129086 Downregulated hsa-let-7b-5p TGAGGTAGTAGGTTGTGTGGTT 82701 116853 81208 48587 Downregulated hsa-miR-30a-5p TGTAAACATCCTCGACTGGAAG 143946 97103 178925 183651 Downregulated hsa-miR-30b-5p TGTAAACATCCTACACTCAGCT 383303 264659 372314 346935 Downregulated hsa-miR-141-3p_R-1 TAACACTGTCTGGTAAAGATG 45058 66296 119600 65598 Downregulated hsa-miR-148a-3p TCAGTGCACTACAGAACTTTGT 386987 588485 918411 876058 Downregulated hsa-miR-148b-3p_R-1 TCAGTGCATCACAGAACTTTG 20149 21809 40891 61755 Downregulated hsa-miR-200c-3p TAATACTGCCGGGTAATGATGGA 764438 473643 254207 253470 Downregulated hsa-miR-200b-3p TAATACTGCCTGGTAATGATGA 354432 251845 266377 258231 Downregulated hsa-miR-200a-3p_R+1 TAACACTGTCTGGTAACGATGTT 345502 350091 385973 393857 Downregulated hsa-miR-335-5p_R-2 TCAAGAGCAATAACGAAAAAT 27462 21489 35648 31513 Downregulated hsa-miR-375-3p TTTGTTCGTTCGGCTCGCGTGA 170762 305772 53533 42830 Downregulated
