Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage

Figure 5

Ambroxol mitigates microglial activation and reduces proinflammatory cytokine accumulation. (a) The representative immunohistochemistry staining showed CD16/32 expression around the hematoma after ICH in different groups. Scale bar: 200 μm and 20 μm for enlarge images, respectively. (b) Statistical graph for CD16/32⁺ area cells per high power field according to the immunohistochemistry staining, , . (c) Quantification of the number of CD16/32⁺ per high power field according to the immunohistochemistry staining, , . (d) Representative bands showed the expression of IL-β and TNF-α. (e) Bar graph summarized the expression of IL-β from (d). ; NS: not significant, . (f) Quantification of the expression of TNF-α from (d). , .

(a)

(b)

(c)

(d)

(e)

(f)