Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage

Figure 6

Ambroxol suppresses endoplasmic reticulum stress involving the IRE1α/TRAF2 signaling pathway. (a) The representative immunostaining showed colabelling of CHOP (green) and CD16/32 (red) around the hematoma after ICH in different groups. Scale bar: 50 μm. (b) Statistical graph for CD16/32⁺ area cells per high power field according to the immunostaining, , . (c) Quantification of the area of CHOP⁺ per high power field according to the immunostaining, , . (d) Bands depicted the expression of IRE1α, TRAF2, and CHOP around the hematoma after ICH in different groups. (e) Bar graph summarized the expression of IRE1α from (d). ; , . (f) Quantification of the TRAF2 expression of from (d). ; , . (g) Quantification of the expression of CHOP from (d). , .

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