Research Article
Association between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality in Critically Ill Patients with Coronary Artery Disease
Table 1
Characteristics of study patients by NPAR tertiles.
| | Characteristics | Total () | Tertiles of NPAR | value | | Tertile 1 () <22.1 | Tertile 2 () ≥22.1, <27.9 | Tertile 3 () ≥27.9 |
| | Age (years) | 72.5 (63.6-81.0) | 69.0 (60.3-78.0) | 73.6 (63.9-81.9) | 75.0 (66.6-82.6) | <0.001 | | Gender, (%) | <0.001 | | Male | 1975 (63.6) | 723 (70.7) | 644 (60.9) | 608 (59.3) | | | Female | 1131 (36.4) | 300 (29.3) | 414 (39.1) | 417 (40.7) | | | Ethnicity, (%) | | | | | 0.450 | | White | 2241 (72.2) | 727 (71.1) | 783 (74.0) | 731 (71.3) | | | Black | 160 (5.2) | 50 (4.9) | 55 (5.2) | 55 (5.4) | | | Other | 705 (22.6) | 246 (24) | 220 (20.8) | 239 (23.3) | | | BMI (kg/m2) | 27.4 (23.8-31.1) | 28.2 (24.9-31.8) | 27.3 (23.6-31.2) | 26.6 (23.0-30.1) | <0.001 | | HR (beats/minute) | 84 (74-93) | 83 (75-91) | 83 (73-92) | 86 (75-96) | <0.001 | | SBP (mmHg) | 113 (104-123) | 114 (106-124) | 113 (105-124) | 112 (102-122) | <0.001 | | DBP (mmHg) | 56 (51-63) | 58 (53-64) | 57 (51-64) | 55 (50-62) | <0.001 | | MBP (mmHg) | 74 (69-81) | 75 (71-81) | 74 (69-81) | 73 (67-80) | <0.001 | | AMI, (%) | 93 (3.0) | 19 (1.9) | 32 (3.0) | 42 (4.1) | 0.012 | | Comorbidities and medical history, (%) | | Hypertension | 1476 (47.5) | 596 (58.3) | 478 (45.2) | 402 (39.2) | <0.001 | | Diabetes | 1220 (39.3) | 406 (39.7) | 450 (42.5) | 364 (35.5) | 0.004 | | Hypercholesterolemia | 1258 (40.5) | 521 (50.9) | 407 (38.5) | 330 (32.2) | <0.001 | | CHF | 1576 (50.7) | 420 (41.1) | 615 (58.1) | 541 (52.8) | <0.001 | | AF | 1273 (41.0) | 386 (37.7) | 445 (42.1) | 442 (43.1) | 0.031 | | COPD | 93 (3.0) | 19 (1.9) | 32 (3.0) | 42 (4.1) | 0.012 | | Prior MI | 493 (15.9) | 136 (13.3) | 180 (17.0) | 177 (17.3) | 0.022 | | Prior stroke | 95 (3.1) | 22 (2.2) | 37 (3.5) | 36 (3.5) | 0.120 | | Laboratory parameters | | Neutrophil (%) | 80.7 (72.0-87.0) | 70.3 (63.0-77.2) | 82.1 (76.0-87.0) | 86.5 (81.1-95.0) | <0.001 | | Albumin (g/dL) | 3.2 (2.7-3.7) | 3.8 (3.5-4.0) | 3.3 (3.0-3.5) | 2.5 (2.3-2.8) | <0.001 | | WBC (109/L) | 10.0 (7.5-13.0) | 9.3 (7.0-12.1) | 10.0 (7.6-13.0) | 10.9 (7.9-13.9) | <0.001 | | Hemoglobin (g/dL) | 10.3 (9.3-11.5) | 10.6 (9.5-11.9) | 10.4 (9.4-11.5) | 10.0 (9.1-10.9) | <0.001 | | Hematocrit (%) | 30.7 (27.8-34.0) | 31.0 (27.9-34.9) | 31.0 (28.2-34.2) | 31.0 (27.4-32.7) | <0.001 | | Platelet (109/L) | 208.0 (149.0-289.0) | 195.0 (146.0-262.0) | 207.0 (151.0-288.0) | 228.0 (151.0-316.0) | <0.001 | | Glucose (mg/dL) | 123.0 (100.0-155.0) | 122.0 (101.0-151.0) | 125.0 (102.0-159.0) | 121.0 (98.0-155.0) | 0.077 | | LDL-C (mg/dL) | 78.0 (57.0-107.0) | 86.0 (64.0-117.0) | 77.0 (57.0-103.0) | 68.0 (50.0-97.5) | <0.001 | | HDL-C (mg/dL) | 42.0 (33.0-51.0) | 43.0 (36-51) | 42.0 (33.0-52.0) | 39.0 (30.0, 51.0) | 0.001 | | TC (mg/dL) | 148.0 (118.0-181.0) | 160.0 (130.0-192.0) | 145.0 (118.0-177.0) | 134.0 (107.0-169.0) | <0.001 | | Troponin T (ng/mL) | 0.09 (0.02-0.45) | 0.07 (0.01-0.39) | 0.1 (0.02-0.53) | 0.09 (0.02-0.42) | 0.001 | | Creatinine (mEq/L) | 1.1 (0.8-1.7) | 1.0 (0.8-1.4) | 1.1 (0.8-1.9) | 1.2 (0.8-2.1) | <0.001 | | BUN (mg/dL) | 25.0 (17.0-40.0) | 21.0 (15.0-30.0) | 26.0 (18.0-42.0) | 29 (19.0-48.0) | <0.001 | | Sodium (mmol/L) | 138.0 (135.0-141.0) | 138.0 (136.0-140.0) | 138.0 (135.0-141.0) | 139.0 (135.0-142.0) | <0.001 | | Potassium (mmol/L) | 4.1 (3.8-4.5) | 4.2 (3.9-4.4) | 4.2 (3.8-4.4) | 4.2 (3.8-4.4) | 0.469 | | PT (seconds) | 13.6 (12.7-15.2) | 13.3 (12.5-14.3) | 13.8 (12.8-15.6) | 13.9 (12.9-15.6) | <0.001 | | APTT (seconds) | 29.8 (26.2-38.9) | 29.0 (25.8-37.7) | 30.4 (26.4-39.4) | 30.0 (26.4-39.4) | 0.007 | | INR | 1.2 (1.1-1.4) | 1.1 (1.1-1.3) | 1.2 (1.1-1.5) | 1.2 (1.1-1.5) | <0.001 | | ALT (U/L) | 26 (17-40) | 25 (17-40) | 27 (17-42) | 29 (16-40) | 0.140 | | CRP | 13.0 (7.3-23.0) | 9.4 (5.2-18.4) | 11.0 (7.0-17.0) | 19.5 (12.4-29.7) | <0.001 | | Medication use | | Aspirin | 2911 (93.7) | 957 (93.5) | 991 (93.7) | 963 (94.0) | 0.928 | | Thienopyridines | 1187 (38.2) | 399 (39.0) | 445 (42.1) | 343 (33.5) | <0.001 | | Oral anticoagulants | 842 (27.1) | 283 (27.7) | 322 (30.4) | 237 (23.1) | 0.001 | | Beta-blockers | 2434 (78.4) | 886 (84.7) | 827 (78.2) | 741 (72.3) | <0.001 | | ACEIs | 1439 (46.3) | 545 (53.3) | 492 (46.5) | 402 (39.2) | <0.001 | | ARBs | 238 (7.7) | 89 (8.7) | 95 (9.0) | 54 (5.3) | 0.002 | | Statins | 2013 (67.7) | 803 (78.5) | 725 (68.5) | 575 (56.1) | <0.001 | | Scoring systems | | SOFA | 5 (3-7) | 4 (2-6) | 4 (3-7) | 5 (3-8) | <0.001 | | SAPS II | 39.0 (31.0-49.0) | 36.0 (29.0-44.5) | 40.0 (32.0-47.0) | 43.0 (34.0-52.0) | <0.001 | | NPAR | 24.7 (20.8-30.0) | 19.1 (16.8-20.7) | 24.7 (23.2-26.2) | 32.9 (30.0-37.4) | <0.001 |
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Data are described as count (percentage) for categorical variables and median (interquartile range) for continuous variables. BMI: body mass index; HR: heart beat; SBP: systolic blood pressure; DBP: diastolic blood pressure; MBP: mean blood pressure; AMI: acute myocardial infarction; CHF: chronic heart failure; AF: atrial fibrillation; COPD: chronic obstructive pulmonary disease; prior MI: prior myocardial infarction; WBC: white blood cell; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TC: total cholesterol; BUN: blood urea nitrogen; PT: prothrombin time; APTT: activated partial thromboplastin time; INR: international normalization ratio; ALT: alanine aminotransferase; CRP: C-reactive protein; ACEIs: angiotensin-converting enzyme inhibitors; ARBs: angiotensin receptor blockers; SOFA: sequential organ failure assessment score [ 13]; SAPS II: simplified acute physiology score II [ 14]. |
