Association between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality in Critically Ill Patients with Coronary Artery Disease

Table 4

Subgroup analysis of associations between 30-day all-cause mortality and NPAR.

		(reference)	HR (95% CIs)	HR (95% CIs)	for interaction
AMI					0.886
No	3013	1.0 (ref)	2.480 (1.904, 3.230)	3.951 (3.072, 5.082)
Yes	93	1.0 (ref)	1.450 (0.281, 7.477)	2.878 (0.644, 12.863)
CHF					0.862
No	1530	1.0 (ref)	2.946 (1.956, 4.438)	4.618 (3.149, 6.771)
Yes	1576	1.0 (ref)	1.899 (1.353, 2.666)	3.172 (2.290, 4.393)
AF					0.912
No	1833	1.0 (ref)	2.069 (1.470, 2.912)	3.594 (2.610, 4.949)
Yes	1273	1.0 (ref)	3.013 (2.000, 4.540)	4.398 (2.960, 6.535)
Hypertension					0.066
No	1630	1.0 (ref)	2.197 (1.558, 3.099)	3.169 (2.281, 4.403)
Yes	1476	1.0 (ref)	2.459 (1.641, 3.682)	4.528 (3.094, 6.629)
Diabetes					0.934
No	1886	1.0 (ref)	2.585 (1.839, 3.632)	4.044 (2.936, 5.571)
Yes	1220	1.0 (ref)	2.269 (1.511, 3.406)	3.757 (2.534, 5.568)
Hypercholesterolemia					0.149
No	1848	1.0 (ref)	2.190 (1.572, 3.051)	3.324 (2.426, 4.555)
Yes	1258	1.0 (ref)	2.635 (1.722, 4.032)	4.573 (3.043, 6.872)
Prior MI					0.428
No	2613	1.0 (ref)	2.428 (1.822, 3.236)	4.020 (3.064, 5.276)
Yes	493	1.0 (ref)	2.412 (1.288, 4.518)	3.371 (1.835, 6.190)
Beta-blockers					0.700
No	672	1.0 (ref)	2.722 (1.639, 4.520)	3.715 (2.283, 6.046)
Yes	2434	1.0 (ref)	2.183 (1.605, 2.968)	3.590 (2.682, 4.806)
Oral anticoagulant					0.560
No	2264	1.0 (ref)	2.512 (1.895, 3.330)	3.744 (2.866, 4.890)
Yes	842	1.0 (ref)	2.494 (1.250, 4.976)	4.468 (2.288, 8.725)
ACEIs					0.907
No	1667	1.0 (ref)	2.142 (1.567, 2.927)	3.473 (2.590, 4.655)
Yes	1439	1.0 (ref)	2.830 (1.761, 4.548)	3.649 (2.278, 5.845)
ARBs					0.452
No	2868	1.0 (ref)	2.482 (1.903, 3.237)	3.811 (2.960, 4.907)
Yes	238	1.0 (ref)	1.912 (0.478, 7.645)	5.299 (1.435, 19.577)
BUN (mg/dL)					0.003
<25	1542	1.0 (ref)	3.535 (2.108, 5.929)	5.892 (3.579, 9.701)
≥25	1564	1.0 (ref)	1.596 (1.180, 2.159)	2.358 (1.772, 3.139)
Glucose (mg/dL)					0.485
<123	1540	1.0 (ref)	2.052 (1.387, 3.037)	3.443 (2.393, 4.954)
≥123	1566	1.0 (ref)	2.767 (1.946, 3.934)	4.421 (3.149, 6.209)
Platelet (10^9/L)					0.858
<208	1539	1.0 (ref)	2.287 (1.641, 3.187)	3.990 (2.905, 5.480)
≥208	1567	1.0 (ref)	2.824 (1.844, 4.327)	4.321 (2.880, 6.482)
WBC (10^9/L)					0.134
<10	1409	1.0 (ref)	2.010 (1.357, 2.976)	2.797 (1.898, 4.123)
≥10	1697	1.0 (ref)	2.750 (1.931, 3.917)	4.426 (3.167, 6.185)
ALT (U/L)					0.436
<26	1488	1.0 (ref)	2.647 (1.793, 3.909)	4.349 (3.001, 6.304)
≥26	1618	1.0 (ref)	2.264 (1.593, 3.216)	3.545 (2.540, 4.949)
INR					0.046
<1.2	1272	1.0 (ref)	2.639 (1.685, 4.133)	4.993 (3.289, 7.581)
≥1.2	1834	1.0 (ref)	2.151 (1.559, 2.968)	3.178 (2.334, 4.328)
LDL-C (mg/dL)					0.380
<84.1	1539	1.0 (ref)	2.059 (1.441, 2.942)	3.355 (2.402, 4.868)
≥84.1	1567	1.0 (ref)	2.852 (1.946, 4.179)	4.365 (3.010, 6.330)
HDL-C (mg/dL)					0.732
<43.5	1552	1.0 (ref)	2.312 (1.592, 3.356)	3.842 (2.711, 5.444)
≥43.5	1554	1.0 (ref)	2.574 (1.787, 3.708)	3.915 (2.744, 5.585)
TC (mg/dL)					0.452
<153.6	1517	1.0 (ref)	2.458 (1.672, 3.614)	3.663 (2.528, 5.307)
≥153.6	1589	1.0 (ref)	2.457 (1.724, 3.503)	4.182 (2.995, 5.839)
Troponin T (ng/mL)					0.644
<0.02	1446	1.0 (ref)	1.960 (1.297, 2.960)	3.731 (2.565, 5.427)
≥0.02	1660	1.0 (ref)	2.622 (1.860, 3.697)	3.890 (2.789, 5.425)
CRP (mg/L)					0.127
<13.0	1550	1.0 (ref)	2.791 (2.023, 3.849)	3.894 (2.736, 5.541)
≥13.0	1556	1.0 (ref)	1.959 (1.254, 3.061)	4.053 (2.732, 6.014)
SOFA					0.099
<5	1513	1.0 (ref)	2.262 (1.408, 3.634)	4.510 (2.882, 7.059)
≥5	1593	1.0 (ref)	2.484 (1.817, 3.396)	3.288 (2.441, 4.430)
SAPS II					0.002
<39	1472	1.0 (ref)	4.189 (2.310, 7.597)	7.064 (3.940, 12.662)
≥39	1634	1.0 (ref)	1.789 (1.337, 2.395)	2.477 (1.883, 3.259)
BMI (kg/m^2)					0.297
<27.4	1564	1.0 (ref)	2.245 (1.578, 3.194)	3.412 (2.444, 4.764)
≥27.4	1542	1.0 (ref)	2.579 (1.749, 3.802)	4.296 (2.959, 6.235)
SBP (mmHg)					0.410
<113	1547	1.0 (ref)	2.421 (1.720, 3.408)	3.564 (2.574, 4.933)
≥113	1559	1.0 (ref)	2.421 (1.617, 3.625)	4.206 (2.865, 6.174)
DBP (mmHg)					0.465
<57	1561	1.0 (ref)	3.066 (2.053, 4.579)	4.711 (3.211, 6.913)
≥57	1545	1.0 (ref)	2.201 (1.425, 2.866)	3.355 (2.404, 4.682)
HR (beats/minute)					0.149
<84	1570	1.0 (ref)	3.182 (2.135, 4.743)	5.012 (3.398, 7.393)
≥84	1536	1.0 (ref)	1.957 (1.382, 2.771)	3.155 (2.286, 4.356)
ICU LOS (day)					0.004
<3.3	1554	1.0 (ref)	3.009 (2.060, 4.397)	5.284 (3.641, 7.671)
≥3.3	1552	1.0 (ref)	1.832 (1.279, 2.624)	2.709 (1.937, 3.788)

HR: hazard ratio; CI: confidence interval. AMI: acute myocardial infarction; CHF: chronic heart failure; AF: atrial fibrillation; Prior MI: prior myocardial infarction; ACEIs: angiotensin-converting enzyme inhibitors; ARBs: angiotensin receptor blockers; BUN: blood urea nitrogen; WBC: white blood cell; ALT: alanine aminotransferase; INR: international normalization ratio; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TC: total cholesterol; CRP: C-reactive protein; SOFA: sequential organ failure assessment score; SAPS II: simplified acute physiology score II; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart beat; ICU LOS: length of ICU stay.