Uncovering PD-L1 and CD8⁺ TILS Expression and Clinical Implication in Cervical Squamous Cell Carcinoma

Table 1

The links between PD-L1 and CD8+ TILS expression in CSCC and clinical pathological profile.

Clinicopathological features	PD-L1 in tumor cell			Intraepithelial CD8^+ TILS
	Positive (≥1%), (%)	Negative (<1%), (%)		Highly expressed (≥17.6/HPF), (%)	Lowly expressed (<17.6/HPF), (%)
Age (years)
≤47	32 (62.7)	19 (37.3)	0.750	30 (58.8)	21 (41.2)	0.083
>47	29 (65.9)	15 (34.1)		18 (40.9)	26 (59.1)
Tumor size (cm)
<3 cm	25 (49.0)	26 (51.0)	0.001	28 (54.9)	23 (45.1)	0.361
≥3 cm	36 (81.8)	8 (18.2)		20 (45.5)	24 (54.5)
Interstitial infiltration
<1/2	11 (37.9)	18 (62.1)	0.001	15 (51.7)	14 (48.3)	0.878
≥1/2	50 (75.8)	16 (24.2)		33 (50.0)	33 (50.0)
FIGO stage
I~II	44 (57.1)	33 (42.9)	0.003	45 (58.4)	32 (41.6)	0.002
III~IV	17 (94.4)	1 (5.6)		3 (16.7)	15 (83.3)
Degree of differentiation
Moderately high differentiation	45 (59.2)	31 (40.8)	0.043	44 (57.9)	32 (42.1)	0.004
Low differentiation	16 (84.2)	2 (15.8)		4 (21.1)	15 (78.9)
Vascular invasion
No	25 (52.1)	23 (47.9)	0.013	23 (47.9)	25 (52.1)	0.609
Yes	36 (76.6)	11 (23.4)		25 (53.2)	22 (46.8)
Lymph node metastasis
No	36 (52.2)	33 (47.8)	0.001	41 (59.4)	28 (40.6)	0.005
Yes	25 (96.2)	1 (3.8)		7 (26.9)	19 (73.1)