No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis
Table 1
Comparison between patients with and without stroke.
Variables
Stroke
No stroke
value
No. pts
Median (range) or frequency (percentage)
No. pts
Median (range) or frequency (percentage)
Age (years)
31
60.21 (38.72-77.30)
318
54.21 (20.57-88.73)
0.003
Gender (male)
31
25 (80.6%)
318
230 (72.3%)
0.319
Systolic blood pressure (mmHg)
31
125.00 (90.00-173.00)
317
122.00 (83.00-193.00)
0.594
Diastolic blood pressure (mmHg)
31
75.00 (50.00-117.00)
317
75.00 (34.00-118.00)
0.844
Etiology of liver diseases
Hepatitis B virus infection
31
10 (32.3%)
318
125 (39.3%)
0.442
Hepatitis C virus infection
31
1 (3.2%)
318
20 (6.3%)
0.494
Alcohol abuse
31
20 (64.5%)
318
139 (43.7%)
0.026
Drug related
31
4 (12.9%)
318
21 (6.6%)
0.194
Budd-Chiari syndrome
31
0 (0.0%)
318
1 (0.3%)
0.755
Autoimmune liver diseases
31
0 (0.0%)
318
22 (6.9%)
0.130
Clinical presentations at admission
Hepatic encephalopathy
31
1 (3.2%)
318
8 (2.5%)
0.812
Acute gastrointestinal bleeding
31
9 (29.0%)
318
101 (31.8%)
0.755
Ascites (no/mild/moderate-severe)
31
16 (51.6%)/8 (25.8%)/7 (22.6%)
318
127 (39.9%)/108 (34.0%)/83 (26.1%)
0.440
History
History of venous thrombus
31
0 (0.0%)
318
7 (2.2%)
0.404
History of hematological diseases
31
1 (3.2%)
318
5 (1.6%)
0.499
History of diabetes mellitus
31
8 (25.8%)
318
51 (16.0%)
0.166
History of arterial hypertension
31
12 (38.7%)
318
41 (12.9%)
<0.001
History of smoking
31
21 (67.7%)
318
135 (42.5%)
0.007
History of cardiac diseases
31
5 (16.1%)
318
23 (7.2%)
0.082
Laboratory tests
Red blood cell (1012/L)
31
3.33 (1.15-5.20)
318
3.27 (1.45-5.46)
0.432
Hemoglobin (g/L)
31
101.00 (37.00-174.00)
318
92.50 (28.00-156.00)
0.104
White blood cell (109/L)
31
4.50 (1.30-22.70)
318
3.40 (0.70-20.80)
0.001
Platelet (109/L)
31
86.00 (37.00-377.00)
318
73.00 (19.00-470.00)
0.169
Total bilirubin (μmol/L)
31
21.10 (5.70-132.70)
318
22.00 (5.20-281.10)
0.775
Direct bilirubin (μmol/L)
31
8.90 (2.00-78.20)
318
9.45 (2.00-210.40)
0.920
Indirect bilirubin (μmol/L)
31
11.90 (3.60-76.00)
318
11.30 (3.20-93.80)
0.677
Albumin (g/L)
31
32.50 (22.10-44.50)
316
32.35 (14.20-50.60)
0.482
Alanine aminotransferase (U/L)
31
20.06 (7.74-176.68)
318
24.34 (4.23-613.24)
0.396
Aspartate aminotransferase (U/L)
31
30.73 (9.74-143.00)
318
34.33 (9.63-761.63)
0.824
Alkaline phosphatase (U/L)
31
88.23 (28.83-337.00)
318
94.40 (31.00-983.93)
0.641
γ-Glutamyl transpeptidase (U/L)
31
70.00 (10.00-1779.18)
318
42.64 (7.54-1283.02)
0.121
Blood urea nitrogen (mmol/L)
31
5.85 (3.52-47.25)
314
5.31 (0.64-24.80)
0.226
Serum creatinine (μmol/L)
31
70.90 (42.82-267.63)
314
64.07 (23.83-178.55)
0.228
Potassium (mmol/L)
31
4.01 (2.80-5.41)
317
3.86 (2.42-5.28)
0.066
Sodium (mmol/L)
31
138.00 (134.10-145.50)
317
138.90 (118.00-152.90)
0.574
Homocysteine (μmol/L)
16
10.49 (6.70-31.79)
170
9.16 (1.59-102.81)
0.145
Total cholesterol (mmol/L)
20
3.68 (1.82-6.58)
208
3.11 (1.14-6.29)
0.148
Triglyceride (mmol/L)
20
0.83 (0.41-6.22)
208
0.85 (0.35-4.81)
0.661
High-density lipoprotein (mmol/L)
20
0.93 (0.47-1.39)
208
0.94 (0.24-2.29)
0.766
Low-density lipoprotein (mmol/L)
20
2.12 (0.99-4.37)
208
1.65 (0.47-4.06)
0.013
Lipoprotein α (mg/L)
20
88.70 (17.90-466.40)
208
63.20 (3.60-911.40)
0.108
Prothrombin time (seconds)
31
15.30 (12.70-20.40)
314
15.70 (10.30-28.00)
0.188
International normalized ratio
31
1.23 (0.99-1.75)
314
1.27 (0.89-2.77)
0.164
Activated partial thromboplastin time (seconds)
31
40.20 (19.80-53.80)
314
39.90 (23.10-71.30)
0.808
D-dimer (mg/L)
19
1.32 (0.16-10.56)
252
0.86 (0.10-46.17)
0.873
Antithrombin III (%)
11
65.30 (40.00-84.00)
118
63.00 (21.00-123.00)
0.933
Protein C activity (%)
6
57.30 (49.80-75.10)
54
59.65 (24.00-119.30)
0.721
Protein S activity (%)
6
61.55 (55.60-73.30)
54
63.50 (20.70-123.60)
0.873
Child-Pugh score
31
7.00 (5.00-10.00)
313
7.00 (5.00-13.00)
0.837
MELD score
31
10.46 (7.23-18.00)
312
10.41 (6.43-30.03)
0.736
Portal vein thrombosis
31
8 (25.8%)
318
92 (28.9%)
0.713
LPV
4 (12.9%)
25 (7.9%)
0.332
RPV
2 (6.5%)
31 (9.7%)
0.549
MPV
4 (12.9%)
52 (16.4%)
0.617
Confluence of SMV and SV
5 (16.1%)
35 (11.0%)
0.393
SMV
2 (6.5%)
51 (16.0%)
0.156
SV
0 (0.0%)
13 (4.1%)
0.251
No. pts: number of patients; MELD: model for the end-stage liver diseases; LPV: left portal vein; RPV: right portal vein; MPV: main portal vein; SMV: superior mesenteric vein; SV: splenic vein.