No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis
Table 2
Comparison between patients with ischemic stroke and those without stroke.
Variables
Ischemic stroke
No stroke
value
No. pts
Median (range) or frequency (percentage)
No. pts
Median (range) or frequency (percentage)
Age (years)
29
61.08 (38.72-77.30)
318
54.21 (20.57-88.73)
0.002
Gender (male)
29
23 (79.3%)
318
230 (72.3%)
0.418
Systolic blood pressure (mmHg)
29
124.00 (90.00-173.00)
317
122.00 (83.00-193.00)
0.975
Diastolic blood pressure (mmHg)
29
73.00 (50.00-108.00)
317
75.00 (34.00-118.00)
0.700
Etiology of liver diseases
Hepatitis B virus infection
29
10 (34.5%)
318
125 (39.3%)
0.610
Hepatitis C virus infection
29
1 (3.4%)
318
20 (6.3%)
0.539
Alcohol abuse
29
19 (65.5%)
318
139 (43.7%)
0.024
Drug related
29
4 (13.8%)
318
21 (6.6%)
0.152
Budd-Chiari syndrome
29
0 (0.0%)
318
1 (0.3%)
0.762
Autoimmune liver diseases
29
0 (0.0%)
318
22 (6.9%)
0.143
Clinical presentations at admission
Hepatic encephalopathy
29
1 (3.4%)
318
8 (2.5%)
0.762
Acute gastrointestinal bleeding
29
8 (27.6%)
318
101 (31.8%)
0.643
Ascites (no/mild/moderate-severe)
29
15 (51.7%)/7 (24.1%)/7 (24.1%)
318
127 (39.9%)/108 (34.0%)/83 (26.1%)
0.424
History
History of venous thrombus
29
0 (0.0%)
318
7 (2.2%)
0.420
History of hematological diseases
29
1 (3.4%)
318
5 (1.6%)
0.458
History of diabetes mellitus
29
8 (27.6%)
318
51 (16.0%)
0.113
History of arterial hypertension
29
11 (37.9%)
318
41 (12.9%)
<0.001
History of smoking
29
20 (69.0%)
318
135 (42.5%)
0.006
History of cardiac diseases
29
5 (17.2%)
318
23 (7.2%)
0.058
Laboratory tests
Red blood cell (1012/L)
29
3.33 (1.15-5.20)
318
3.27 (1.45-5.46)
0.471
Hemoglobin (g/L)
29
101.00 (37.00-174.00)
318
92.50 (28.00-156.00)
0.126
White blood cell (109/L)
29
4.90 (1.30-22.70)
318
3.40 (0.70-20.80)
<0.001
Platelet (109/L)
29
90.00 (37.00-377.00)
318
73.00 (19.00-470.00)
0.068
Total bilirubin (μmol/L)
29
25.10 (5.70-132.70)
318
22.00 (5.20-281.10)
0.606
Direct bilirubin (μmol/L)
29
9.00 (2.00-78.20)
318
9.45 (2.00-210.40)
0.892
Indirect bilirubin (μmol/L)
29
12.40 (3.60-76.00)
318
11.30 (3.20-93.80)
0.576
Albumin (g/L)
29
31.10 (22.10-44.50)
316
32.35 (14.20-50.60)
0.401
Alanine aminotransferase (U/L)
29
21.33 (7.74-176.68)
318
24.34 (4.23-613.24)
0.643
Aspartate aminotransferase (U/L)
29
31.44 (9.74-143.00)
318
34.33 (9.63-761.63)
0.902
Alkaline phosphatase (U/L)
29
92.49 (28.83-337.00)
318
94.40 (31.00-983.93)
0.921
γ-Glutamyl transpeptidase (U/L)
29
70.00 (10.00-1779.18)
318
42.64 (7.54-1283.02)
0.073
Blood urea nitrogen (mmol/L)
29
5.82 (3.52-47.25)
314
5.31 (0.64-24.80)
0.271
Serum creatinine (μmol/L)
29
70.90 (42.82-267.63)
314
64.07 (23.83-178.55)
0.253
Potassium (mmol/L)
29
4.05 (2.80-5.41)
317
3.86 (2.42-5.28)
0.047
Sodium (mmol/L)
29
137.90 (134.10-145.50)
317
138.90 (118.00-152.90)
0.430
Homocysteine (μmol/L)
15
10.47 (6.70-31.79)
170
9.16 (1.59-102.81)
0.179
Total cholesterol (mmol/L)
19
3.77 (1.82-6.58)
208
3.11 (1.14-6.29)
0.104
Triglyceride (mmol/L)
19
0.86 (0.47-6.22)
208
0.85 (0.35-4.81)
0.414
High-density lipoprotein (mmol/L)
19
0.92 (0.47-1.39)
208
0.94 (0.24-2.29)
0.762
Low-density lipoprotein (mmol/L)
19
2.12 (0.99-4.37)
208
1.65 (0.47-4.06)
0.008
Lipoprotein α (mg/L)
19
91.70 (17.90-466.40)
208
63.20 (3.60-911.40)
0.114
Prothrombin time (seconds)
29
15.30 (12.70-20.40)
314
15.70 (10.30-28.00)
0.198
International normalized ratio
29
1.23 (0.99-1.75)
314
1.27 (0.89-2.77)
0.170
Activated partial thromboplastin time (seconds)
29
40.00 (19.80-53.80)
314
39.90 (23.10-71.30)
0.952
D-dimer (mg/L)
19
1.32 (0.16-10.56)
252
0.86 (0.10-46.17)
0.873
Antithrombin III (%)
11
65.30 (40.00-84.00)
118
63.00 (21.00-123.00)
0.933
Protein C activity (%)
6
57.30 (49.80-75.10)
54
59.65 (24.00-119.30)
0.721
Protein S activity (%)
6
61.55 (55.60-73.30)
54
63.50 (20.70-123.60)
0.873
Child-Pugh score
29
7.00 (5.00-10.00)
313
7.00 (5.00-13.00)
0.749
MELD score
29
10.46 (7.23-18.00)
312
10.41 (6.43-30.03)
0.892
Portal vein thrombosis
29
7 (24.1%)
318
92 (28.9%)
0.584
LPV
3 (10.3%)
25 (7.9%)
0.638
RPV
2 (6.9%)
31 (9.7%)
0.616
MPV
4 (13.8%)
52 (16.4%)
0.720
Confluence of SMV and SV
5 (17.2%)
35 (11.0%)
0.314
SMV
2 (6.9%)
51 (16.0%)
0.190
SV
0 (0.0%)
13 (4.1%)
0.267
No. pts: number of patients; MELD: model for the end-stage liver diseases; LPV: left portal vein; RPV: right portal vein; MPV: main portal vein; SMV: superior mesenteric vein; SV: splenic vein.
