The Overexpression of Keratin 23 Promotes Migration of Ovarian Cancer via Epithelial-Mesenchymal Transition

Figure 1

The expression of keratin 23 (KRT23) in ovarian cancer (OC) tissues and cell lines. (a) Gene expression datasets were analyzed in 329 OC tissues and 19 normal tissues that were obtained from the Oncomine database. KRT23 overexpression was found in OC patients. values were calculated using Student’s -test. (b) Immunohistochemical staining of KRT23 in OC tissues () and adjacent normal tissues (), and there were four pairs with positive KRT23 expression in ten paired samples. Scale bars, 50 μm. (c) The levels of KRT23 in all OC cell lines were analyzed by reverse transcription quantitative polymerase chain reaction assay. The KRT23 level was higher in SKOV3 cells and OVCAR3 cells when compared with Human Ovarian Surface Epithelial Cells (HOSEpiC). Glyceraldehyde 3-phosphate dehydrogenase was used as an internal control. .

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