Repurposing Napabucasin as an Antimicrobial Agent against Oral Streptococcal Biofilms

Table 1

MICs, MBCs, MBICs, and MBRCs of NAP and CHX against S. mutans, S. gordonii, and S. sanguinis strains.

Bacterial strain (μg/mL)	Planktonic cells				Biofilm
	MIC		MBC		MBIC		MBRC
	NAP	CHX	NAP	CHX	NAP	CHX	NAP	CHX
S. mutans	3.91	1.95	15.63	7.81	1.95	0.98	62.50	62.50
S. gordonii	0.49	3.91	0.98	7.81	0.49	3.91	15.63	15.63
S. sanguinis	0.49	0.49	15.63	3.91	1.95	1.95	3.91	3.91

MIC: minimum inhibitory concentration; MBC: minimum bactericidal concentration; MBIC: minimum biofilm inhibition concentrations; MBRC: minimum biofilm reduction concentrations.