Pharmacokinetic Study of Thirteen Ingredients after the Oral Administration of Flos Chrysanthemi Extract in Rats by UPLC-MS/MS

Table 4

Extraction recoveries and matrix effects of the analytes ().

Compounds	Spiked concentration (ng/mL)	Extraction recovery (%)	RSD (%)	Matrix effect (%)	RSD (%)
Luteolin	20		2.2		3.3
	200		13.0		7.2
	4000		7.0		3.1
Cynaroside	20		11.7		2.6
	200		10.3		7.7
	4000		3.5		1.9
Luteolin 7-O-glucuronide	10		10.8		2.4
	100		2.9		1.2
	2000		8.2		6.2
Isochlorogenic acid C	5		14.5		14.0
	50		6.1		5.7
	1000		4.2		5.1
Cryptochlorogenic acid	5		13.6		3.4
	50		6.7		7.8
	1000		1.5		2.6
Chlorogenic acid	5		5.5		5.0
	50		9.0		14.0
	1000		6.3		3.5
Apigenin	5		6.1		6.1
	50		4.7		11.3
	1000		7.5		2.6
Acacetin	5		10.1		4.3
	50		8.8		9.1
	1000		7.2		1.9
Hyperoside	5		7.1		4.8
	50		12.4		13.2
	1000		6.2		2.8
Isoquercitrin	5		7.4		3.5
	50		3.0		10.7
	1000		6.1		3.1
Apigenin 7-glucoside	5		8.8		4.2
	50		11.5		7.7
	1000		7.5		3.5
Tilianin	1		14.3		3.2
	10		10.2		11.7
	200		4.6		1.8
Hesperidin	1		13.0		9.3
	10		7.2		11.6
	200		7.4		1.7