NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis

Figure 1

PCR-RFLP of studied polymorphisms. (a) T6746C NOTCH3 polymorphism. Lane 1: Ladder (100 bp); Lanes 2–5, 7, and 11–13: TT genotypes; Lanes 6, 8–10, and 15: CT heterozygotes; Lane 14: CC homozygote. (b) P72R TP53 polymorphism. Lane 1: Ladder (100 bp); Lanes 2 and 6: RR genotypes; Lane 3: PP genotype; Lanes 4 and 5: PR heterozygotes.

(a)

(b)