NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis

Table 1

Inclusion and exclusion criteria of SSc patients and healthy blood donors.

	Inclusion criteria	Exclusion criteria
SSc patients	(i) Adult patients; (ii) Signed informed consent; (iii) Diagnosed with SSc and treated in the Chair and Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, Poland; (iv) Unrelated individuals; (v) Caucasian race from South-Western Poland	(i) Other connective tissue diseases, SSc-like illnesses related to exposures or ingestions; (ii) Non-Caucasian in race
Control group	(i) Adult, healthy blood donors; (ii) Signed informed consent; (iii) Agreed to have blood donated and stored for research in Regional Blood Donation and Blood Treatment Center in Kielce, Poland; (iv) Caucasian race from South-Western Poland	(i) Known to be infected with HIV, syphilis, tuberculosis, hepatitis B or hepatitis C; (ii) A condition in which repeated blood draws or injections pose more than minimal risk for the subject such as hemophilia, other severe coagulation disorders, or significantly impaired venous access; (iii) A condition that requires active medical intervention or monitoring to avert serious danger to the participant's health or well-being; (iv) Non-Caucasian in race