NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis

Table 3

Hardy-Weinberg equilibrium for NOTCH3 and TP53 polymorphisms in the case and control groups according to expected E and observed O values.

	TT	CT	CC	Total	HWE value and χ^2	RR	PR	PP	Total	HWE value and χ^2
Control	NOTCH3					TP53
E	67	30	3	100	, χ^2 = 0.38	59	36	5	100	, χ^2 = 0.22
O	66	32	2	100		59	35	6	100
Case
E	94	28	2	124	, χ^2 = 4.63	72	44	7	124	, χ^2 = 0.43
O	97	22	5	124		73	47	5	124

If χ² ≤ 3.84 and the corresponding p ≥ 0.05, then the population is in HWE.