Overexpression of MicroRNA-16 Alleviates Atherosclerosis by Inhibition of Inflammatory Pathways
Expression and roles of miR-16 in coronary artery disease (CAD) patients and association of miR-16 expression and the severity of CAD evaluated by Gensini score. Relative miR-16 expression level in peripheral blood mononuclear cells (a) and plasma (b); ELISA detection of the protein levels of IL-6 (c) and IL-10 (d) in patients with chest pain symptoms but safely excluded by coronary angiogram () and from CAD patients who had at least one diseased vessel (). (e) IL-10/IL-6 ratio; the Spearman correlation analysis to indicate the association of miR-16 levels and IL-6 (f), IL-10 (g), or IL-10/IL-6 (h). The Spearman correlation analysis to indicate miR-16 expression level in peripheral blood mononuclear cells (i), plasma (j), and Gensini score. Data are represented as the ;, compared with control.
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