Potent In Vitro α-Glucosidase and β-Secretase Inhibition of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus (Angel’s Trumpet) Fruits

Table 2

β-Secretase inhibitory activity of extract/fractions and isolated daturaolone (1).

Sample/standard	Concentration	% inhibition	(μM)
Hexane	0.2 μg	38.28	NA
Chloroform	0.2 μg	88.27
Ethyl acetate	0.2 μg	67.98
Methanol	0.2 μg	78.42
Daturaolone (1)	0.2 μM	95.19
Standard	0.2 μM	94.21

IC₅₀: minimum inhibitory concentration; SEM: standard error of mean; μM: micromolar; Standard: (Ans670, Sta671, Val672)-amyloid-β/A4 precursor protein 770 fragments 662-675).