Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma

Figure 5

Identification of ATAD2-related genes and GO and KEGG pathway analysis of the ATAD2-related genes in HCC. (a) Volcano plot of the differential expression genes in HCC vs. normal liver tissues based on TCGA. Red indicates high expression and green indicates low expression ( and adjusted value <0.05). (b, c) The -axis showed the number of genes and the -axis showed the GO and KEGG terms; (d) Heat map of the correlation between module eigengenes and clinical traits including ATAD2 aberrant expressions of HCC by using the WGCNA package of R language: each row indicated a module eigengene, and each column indicated a clinicopathological parameter. Each block contained the corresponding correlation coefficient and value. (e) Scatter plot of module eigengenes related to ATAD2 aberrant expression in the yellow set. (f) Hub genes were filtered out with module membership (MM), gene significance (GS), and MCODE degree. (g) Protein-protein interaction network of ATAD2, TTK, KIFC1, SGO1, GINS1, and TPX2 in the yellow set.

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