Research Article

Conservative Treatment of Interstitial Ectopic Pregnancy with the Combination of Mifepristone and Methotrexate: Our Experience and Review of the Literature

Table 1

Management of IPs with MTX and Oral Mifepristone: β-hCG: Beta Human Chorionic Gonadotropin; MTX: Methotrexate; CRL: crown-rump length; IM: intramuscular.

ReferenceNo. casesInitial β-hCG (mUi/mL)ManagementTime until β-hCG undetectable (days)Outcomes

Case1119397Mifepristone Folinic acid30Complete resolution (presence of an embryo with CRL 3.6 mm)
Case212664Mifepristone of body surface
(two doses)
47Complete resolution (no evidence of embryo)
Bremner et al. 2000 [24]23724-4116Oral mifepristone of body surface35-49Complete resolution
Karki and Saha 2016 [21]1594,8Oral mifepristone of body surface42Complete resolution
Narang at Kalu 2009 [26]28465-3700Laparoscopic salpingocentesis+local MTX of body surface+oral mifepristone 200 mgComplete resolution