Novel Model to Predict the Prognosis of Patients with Stage II–III Colon Cancer

Table 3

Univariate analysis and multivariate analysis in the training set.

Variables		Univariate analysis			Multivariate analysis
		HR	95% CI	value	HR	95% CI	value
Sex	Male	ref	—	—
	Female	1.120	0.693-1.812	0.644
Age (median, y)	59	0.996	0.978-1.014	0.658
Tumour site	Left	ref	—	—
	Right	1.066	0.663-1.712	0.793
BMI (kg/m^2)	21.3	1.001	0.964-1.039	0.957
Tumour diameter	5.3	0.980	0.970-1.105	0.745
ASA grade	1/2	ref	—	—
	3	0.711	0.495-1.110	0.425
Comorbidities	Absent	ref	—	—
	Present	1.011	0.799-1.103	0.375
Intestinal obstruction	Absent	ref	—	—
	Present	0.666	0.395-1.120	0.125
PLR	206	1.001	0.999-1.003	0.295
NLR	3.2	1.002	0.976-1.028	0.906
CAR	<0.14	ref	—	—	ref	—	—
	≥0.14	1.785	1.086-2.933	0.022	2.271	1.345-3.834	0.002
CEA (median)	0.2	1.002	1.001-1.004	0.011	1.002	1.001-1.003	0.002
CA199 (median)	11.99	1.002	1.001-1.004	<0.001
Postoperative chemotherapy	Absent	ref	—	—
	Present	2.561	1.584-4.140	<0.001
Operation mode	Open	ref	—	—	ref	—	—
	Laparoscopic	0.580	0.360-0.934	0.025	0.601	0.368-0.980	0.041
LNDs	19	0.983	0.608-1.591	0.944
LNM	Absent	ref	—	—	ref	—	—
	Present	2.561	1.584-4.140	<0.001	2.545	1.530-4.235	<0.001
T-stage	T1-2	ref	—	—
	T3	0.879	0.625-1.237	—
	T4	0.913	0.589-1.415	0.048
LVI	Absent	ref	—	—
	Present	2.178	1.341-3.538	0.002
PNI	Absent	ref	—	—	ref	—	—
	Present	2.426	1.384-4.252	0.002	0.601	0.368-0.980	0.012

LND: lymph node dissection; LNM: lymph node metastasis; LVI: lymphovascular invasion; PNI: perineural invasion.