BioMed Research International

Research Article

A Nomogram Model Based on Noninvasive Bioindicators to Predict 3-Year Risk of Nonalcoholic Fatty Liver in Nonobese Mainland Chinese: A Prospective Cohort Study

Table 3

Results of univariate and multivariate analysis for NAFLD risk prediction.


Variables	Univariate analysis		Multivariate analysis
Variables	HR (95% CI)	value	HR (95% CI)	value

Gender
Female	Reference
Male	1.04 (0.92, 1.16)	NS
Age	1.00 (1.00, 1.01)	0.012	0.99 (0.98, 1.01)	NS
ALP	1.01 (1.01, 1.01)	<0.001	1.00 (1.00, 1.00)	NS
AST	1.01 (1.00, 1.01)	<0.001	0.99 (0.97, 1.02)	NS
TP	1.02 (1.01, 1.03)	0.001	1.01 (0.99, 1.02)	NS
ALB	1.04 (1.02, 1.06)	<0.001	0.99 (0.97, 1.02)	NS
GLB	1.01 (0.99, 1.02)	NS
BUN	0.89 (0.85, 0.93)	<0.001	0.90 (0.78, 1.02)	NS
Cr	1.00 (1.00, 1.00)	0.001	1.00 (1.00, 1.00)	NS
UA	1.00 (1.00, 1.00)	<0.001	1.00 (1.00, 1.00)	NS
FPG	1.23 (1.18, 1.28)	<0.001	1.17 (1.11, 1.22)	<0.001
TC	1.29 (1.20, 1.39)	<0.001	0.80 (0.57, 1.03)	NS
HDL-c	0.29 (0.25, 0.35)	<0.001	0.72 (0.55, 0.92)	0.010
LDL-c	1.69 (1.49, 1.91)	<0.001	1.63 (1.31, 2.02)	<0.001
BMI	1.64 (1.58, 1.71)	<0.001	1.43 (1.37, 1.49)	<0.001
SBP	1.01 (1.01, 1.01)	<0.001	0.99 (0.99, 1.00)	NS
DBP	1.03 (1.03, 1.04)	<0.001	1.00 (0.99, 1.01)	NS
Lg (GGT)	6.21 (5.25, 7.34)	<0.001	1.96 (1.51, 2.53)	<0.001
Lg (ALT)	7.82 (6.45, 9.47)	<0.001	5.23 (3.52, 7.78)	<0.001
Lg (TB)	0.60 (0.43, 0.85)	0.004	9.35 (5.86, 14.93)	<0.001
Lg (DBIL)	0.10 (0.08, 0.12)	<0.001	0.06 (0.05, 0.08)	<0.001
Lg (TG)	18.26 (14.65, 22.75)	<0.001	2.62 (1.74, 3.93)	<0.001

NAFLD: nonalcoholic fatty liver disease; ALP: alkaline phosphatase; GGT: γ-glutamyl transpeptidase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TP: total protein; ALB: albumin; GLB: globulin; TB: total bilirubin; DBIL: direct bilirubin; BUN: blood urea nitrogen; Cr: creatinine; UA: uric acid; FPG: fasting plasma glucose; TC: total cholesterol; TG: triglyceride; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: hazard ratio; CI: confidence interval; NS: no significance.