Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest <i>β</i>-Secretase Enzymatic Activity Involved in Alzheimer’s Disease

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/bmri/volume-2020/8934289/figures/8934289.fig.001a.svgz" name="8934289.fig.001a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Compound (5) interactions within the flap conformation of BACE1</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/bmri/volume-2020/8934289/figures/8934289.fig.001b.svgz" name="8934289.fig.001b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>The molecular interactions of compound (8) within the active domain of BACE1</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/bmri/volume-2020/8934289/figures/8934289.fig.001c.svgz" name="8934289.fig.001c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>Compound (9)</td></tr></table>

<div>The possible interaction of compounds (5), (8), and (9) within the active domain of BACE1 that completely arrested the catalytic activity of aspartate residues for this enzyme in a closed conformation of the flap region.</div>

BioMed Research International

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Figure 1: Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest <i>β</i>-Secretase Enzymatic Activity Involved in Alzheimer’s Disease 

Figure 1 | Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest β-Secretase Enzymatic Activity Involved in Alzheimer’s Disease 