Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest β-Secretase Enzymatic Activity Involved in Alzheimer’s Disease

Figure 2

The synthesized compound (9) on the memory/learning behaviors of the mouse models manipulating the available technique of Morris water maze assay. (a) shows the escape latency time period of the mice to arrive at the platform on various trial days of the AlCl₃-triggered neurotoxicity group, the control group, and the compound (9)-treated group. (b) signifies the analysis results among the three groups in terms of escape latency on the test day. (c) establishes the per hundred total time spent of the mice in the investigations of the target quadrant. (d) demonstrates in what manner each time every mouse crisscrossed the targeted quadrant.

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