Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition

Figure 1

(a) Experiment No. 1. Concentration-response curves (CRCs) determined for control conditions and for resveratrol. The curves with a maximum effect of 20–80% differ significantly from the control values (). (b) Experiment No. 2. Concentration-response curves (CRCs) determined under control conditions for phenylephrine, 8Br-cGMP (0.01 mM/l), and resveratrol with 8Br-cGMP at concentrations of 0.01 mM/l and 0.1 mM/l. The curves with a maximum effect of 20–80% differ significantly from the control values (). (c) Experiment No. 3. Concentration-response curves (CRCs) determined under control conditions for phenylephrine, HA-1077 (20 μM/l), and resveratrol with HA-1077 in concentrations of 20 μM/l and 100 μM/l. The curves with a maximum effect of 20–80% differ significantly from the control values (). (d) Experiment No. 4. CRCs determined under control conditions for phenylephrine, Bay K8644 (0.1 mM/l), and resveratrol with Bay K8644 at concentrations of 0.1 mM/l and 0.01 mM/l.

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