Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition

Table 2

Values of EC 50 and E_max in the control and test groups: resveratrol + Bay K8644 in concentrations of 0.1 mM/l and 0.01 mM/l.

	n^1	EC50 (M/l)	Emax (%)^2
Control (Res−)	8	4.53 ± 1.2 × 10^−8	100.0	—
Bay K8644 (0.1 mM/l) (Res−)	10	1.62 ± 0.43 × 10^−8	100 ± 2.0	ns^a
Bay K8644 (0.1 mM/l) + resveratrol	17	5.17 ± 0.72 × 10^−7	87.4 ± 4.2
Bay K8644 (0.01 mM/l) + resveratrol	14	2.13 ± 0.21 × 10^−7	74.7 ± 5.0

¹The number of CRCs used for the calculation; ²E_max calculated as a % of the maximum tissue response to PHE; ^a value calculated relative to the control (Res−); ^b value calculated relative to Bay K8644 (0.1 mM/l) (Res−); ^c value calculated relative to Bay K8644 (0.1 mM/l) (Res+). All data are means ± SD.