Is Lutikizumab, an Anti–Interleukin-1α/β Dual Variable Domain Immunoglobulin, efficacious for Osteoarthritis? Results from a bayesian network meta-analysis

Table 3

Detailed results of network meta-analysis for safety endpoints (Data are odds ratio, from the top left to the bottom right, higher comparator vs. lower comparator, and their related 95% CI).

AEs
	ALI	-0.47 (-1.31 to 0.37)	0.72 (-0.20 to 1.65)	0.02 (-0.81 to 0.85)	0.59 (-0.28 to 1.47)	-0.36 (-1.15 to 0.43)
	0.47 (-0.37 to 1.31)	SCI	1.19 (0.63 to 1.75)	0.49 (0.28 to 0.70)	1.06 (0.65 to 1.48)	0.11 (-0.17 to 0.40)
	-0.72 (-1.65 to 0.20)	-1.19 (-1.75 to -0.63)	Dul	-0.70 (-1.25 to -0.15)	-0.13 (-0.74 to 0.48)	-1.08 (-1.56 to -0.60)
	-0.02 (-0.85 to 0.81)	-0.49 (-0.70 to -0.28)	0.70 (0.15 to 1.25)	NSA	0.57 (0.15 to 0.99)	-0.38 (-0.64 to -0.12)
	-0.59 (-1.47 to 0.28)	-1.06 (-1.48 to -0.65)	0.13 (-0.48 to 0.74)	-0.57 (-0.99 to -0.15)	OPI	-0.95 (-1.33 to -0.57)
	0.36 (-0.43 to 1.15)	-0.11 (-0.40 to 0.17)	1.08 (0.60 to 1.56)	0.38 (0.12 to 0.64)	0.95 (0.57 to 1.33)	Placebo
Serious AEs
	ALI	0.54 (-0.72 to 1.80)	0.58 (-1.03 to 2.19)	1.03 (-0.18 to 2.24)	0.56 (-2.22 to 3.34)	0.55 (-0.50 to 1.60)
	-0.54 (-1.80 to 0.72)	SCI	0.04 (-1.36 to 1.44)	0.49 (0.10 to 0.88)	0.02 (-2.59 to 2.64)	0.01 (-0.68 to 0.70)
	-0.58 (-2.19 to 1.03)	-0.04 (-1.44 to 1.36)	Dul	0.45 (-0.91 to 1.81)	-0.02 (-2.87 to 2.84)	-0.03 (-1.25 to 1.19)
	-1.03 (-2.24 to 0.18)	-0.49 (-0.88 to -0.10)	-0.45 (-1.81 to 0.91)	NSA	-0.47 (-3.08 to 2.14)	-0.48 (-1.08 to 0.12)
	-0.56 (-3.34 to 2.22)	-0.02 (-2.64 to 2.59)	0.02 (-2.84 to 2.87)	0.47 (-2.14 to 3.08)	OPI	-0.01 (-2.59 to 2.57)
	-0.55 (-1.60 to 0.50)	-0.01 (-0.70 to 0.68)	0.03 (-1.19 to 1.25)	0.48 (-0.12 to 1.08)	0.01 (-2.57 to 2.59)	PLA
Any drug-related AEs
	ALI	-0.08 (-0.88 to 0.72)	0.44 (-0.38 to 1.25)	0.20 (-0.60 to 1.00)	0.59 (-0.24 to 1.42)	-0.15 (-0.93 to 0.63)
	0.08 (-0.72 to 0.88)	SCI	0.51 (0.23 to 0.80)	0.28 (0.15 to 0.40)	0.67 (0.36 to 0.98)	-0.07 (-0.24 to 0.10)
	-0.44 (-1.25 to 0.38)	-0.51 (-0.80 to -0.23)	Dul	-0.24 (-0.52 to 0.05)	0.15 (-0.21 to 0.52)	-0.59 (-0.82 to -0.36)
	-0.20 (-1.00 to 0.60)	-0.28 (-0.40 to -0.15)	0.24 (-0.05 to 0.52)	NSA	0.39 (0.08 to 0.70)	-0.35 (-0.51 to -0.19)
	-0.59 (-1.42 to 0.24)	-0.67 (-0.98 to -0.36)	-0.15 (-0.52 to 0.21)	-0.39 (-0.70 to -0.08)	OPI	-0.74 (-1.03 to -0.46)
	0.15 (-0.63 to 0.93)	0.07 (-0.10 to 0.24)	0.59 (0.36 to 0.82)	0.35 (0.19 to 0.51)	0.74 (0.46 to 1.03)	Placebo